The frequency of bowel movements reaches 10 times a day. Signs of exhaustion develop, in severe cases - cachexia. Pain with localization in the navel has a paroxysmal character.
The third stage - systemic lesions - is characterized by the development of neurological symptoms. The central and peripheral nervous system suffers, ataxia, polyneuropathy develops, hearing and visual acuity decrease.
Involvement in the pathological process of the heart is manifested by endocarditis and pericarditis (often pathology is detected only during an echocardiographic study).
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Previous30-50% of patients develop bronchopulmonary pathologies (bronchitis or exudative pleurisy). As a result of an increase in the lymph nodes of the mediastinum and squeezing of the trachea, shortness of breath, dry cough and a feeling of suffocation occur. Whipple's disease is a chronic disease characterized by periods of remission and relapse. According to observations, complications manifest at the moments of relapses that occur in the absence of preventive treatment. The main ones are neurological pathologies, including the progression of dementia, impaired coordination of micardis, hydrocephalus, supranuclear ophthalmoplegia and myoclonus. In the latter case, damage to the spinal cord or cerebral cortex occurs. This leads to involuntary muscle cramps, tremors, as well as a deterioration in the physical and mental state of a person.
Since Whipple's disease is difficult to diagnose in its early stages, most patients are not correctly diagnosed until afterfew years. To confirm the infectious genesis of telmisartan pills and typical pathomorphological changes, the following instrumental and laboratory tests are performed: Endoscopy. When conducting endoscopy revealed swelling, hyperemia, stretching and thickening of the folds of the duodenum.
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The mucous membrane becomes granular, its villi thicken and shorten. Histological examination of micardis pills reveals macrophages with undigested pathogens, PCR analysis can detect Tropheryma whippelii and confirm Whipple's disease, even if only traces of pathogen DNA are present in the sample. Radiation Research. They are of secondary importance. X-ray of the small intestine with contrast enhancement reveals thickening of the mucosa, expansion of the intestine and duodenal flexure. Ultrasound of the mediastinum and abdominal cavity reveals an increase in mediastinal, mesenteric and retroperitoneal lymph nodes. Blood tests . For intestinal lipodystrophy, the development of hypochromic anemia, an increase in ESR, hyperleukocytosis, and thrombocytosis are characteristic. In the blood serum, a deficiency of protein, calcium, iron and cholesterol is found. Albumin synthesis is impaired.
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